ZhixingChenLab | 上线了sxl.cn

Laboratory of Molecular Probe Technology

College of Future Technology,
Institute of Molecular Medicine,
National Biomedical Imaging Center,
Peking-Tsinghua Center for Life Sciences,
Peking University
Research Philosophy
Tailored Molecules for Advanced Imaging and Biotechnology

As an emerging yet interdisciplinary field, bioimaging is revolutionizing biological and medical research. Trained as a general chemist, Dr. Chen has been approaching this field from a molecular aspect. Our lab endeavors to develop novel molecular tools by integrating the essence of chemical synthesis, spectroscopy, polymer, and chemical biology. The molecular tools would be applied as cutting-edge technologies to various fields including biophysics, cell biology, physiology, and finally inspire drug discovery. Our research philosophy features: 1. based on chemical principles, we customize tailored molecules as enabling solutions; 2. we leverage the platforms of CFT and CLS as unique opportunities to bring modern molecular tools to the frontiers of biological sciences and molecular medicine. We believe our training in chemistry and biotechnology, our cross-disciplinary experience, and our problem-solving mindset would broaden the career path of trainees.

Please refer to selected projects to see our accomplishments.
Meet Our Team
Dr. Zhixing Chen 陈知行博士
Principal Investigator
2004-2008 BS in Chem. Biol., Tsinghua University
2008-2009 Research Assistant, Peking University
2009-2014 PhD in Chemistry, Columbia University
2015 PostDoc, Columbia University
2016-2018 Postdoc, Stanford University
2018-2024 Assistant Professor, Peking University
2024- Associate Professor, Peking University
Affiliations:
College of Future Technology, Institute of Molecular Medicine & National Biomedical Imaging Center.
Academy for Advanced Interdisciplinary Studies, Biomed-X Center & Center for Life Sciences.
State Key Lab. of Membrane Biology
Office: 417 Integrated Science Research Center #2
Email: zhixingchen at pku.edu.cn
Dr. Zhixing Chen is a chemist with research experience spanning natural product synthesis, polymer mechano-chemistry, fluorescence and non-linear optical probes, bioconjugation, and live cell imaging. Zhixing believes in the enabling role of molecular technologies at the frontier of optical imaging, biotechnology, and life sciences. His current focus is to develop small and macro molecular tools for advanced imaging technologies. In the long term, Zhixing endeavors to unleash the synergy at the chemistry-biology-imaging interface in a collaborative manner, bringing new dimensions to the fields of molecular imaging and molecular medicine.
Cong Li 李聪
PostDoc
PhD. Integrated Biol. Sci.
Peking University
TianYan Liu 刘天妍
PostDoc (Boya Fellow)
PhD. Integrated Biol. Sci.
Peking University
JunWei Zhang 张钧维
PhD
BE. Chemical Engineering
Dalian Univ. Technology
JingTing Chen 陈婧婷
Graduate Student
BS. Chemistry
Wuhan University
ZhongTian Yang 杨中天
Graduate Student
BS. Chemical Biology
Peking University
RunDong Yu 于润东
Graduate Student
BS. Chemistry
Lanzhou University
KeCheng Zhang 张珂诚
Graduate Student
BS. Biological Sciences
Beijing Normal Univ.
Zhe Yang 杨哲
Graduate Student
MS. Analytical Chemistry
Fuzhou University
MingQiao Liu 刘明樵
Graduate Student
BS. Chemistry
Beijing Institute of Technology
YiTong Liu 刘奕彤
Graduate Student
BS. Chemistry
Nankai University
Dilizhatai Saimi
迪丽扎泰·赛米
Graduate Student
MS. Immunology
Peking Union Medical College
XiaoWen Shen 沈潇雯
Graduate Student
BS. Biological Sciences
Xiamen University
ZhengZhao Chen 陈正昭
Graduate Student
BS. Chemistry
Sichuan University
JiaSheng Du 杜佳晟
Graduate Student
MS. Material Engineering
U Sci Tech Beijing
HaoLin Zhang 张昊霖
Research Assistant
MS. Integrated Biol. Sci.
Peking University
Past Members and their Next Destination
Yuan Zhang (PhD 2019-2024), Postdoc at UC Irvine
Jing Ling (PhD 2019-2024), Postdoc at UCSD
Yu Zhang (PhD/PostDoc 2018-2024), Postdoc at Weill Cornell Medicine
Yihui Nie (Manager 2018-2024), Administrative staff at Hunan U.
Zhibin Li (RA 2021-2023), PhD student at Westlake U.
Xiaohong Peng (Joint PostDoc 2020-2022), PKU Medical School
Jiaming Mo (MS 2018-2022), BGI
Yabo Shi (RA 2018-2019), PhD student at PKU
Yunxiang Wu (RA 2018-2019), PhD student at U. Wisc.
Rui Sang (RA 2018-2019), PhD student at UNSW
Zhaohong Wang (RA 2020-2021), PhD student at Cornell Univ.
Zixuan Chen (UG 2019-2020)

We look for talents at all levels to work together with us! Feel free to explore our mutual interests and the potential research opportunities. Our lab is affiliated to the PhD programs of Institute of Molecular Medicine and Center for Life Sciences. Postdoc and research staff candidates should contact Dr. Chen directly.
Selected Projects
Our research achievements using elaborately tailored molecules to advance science at different frontiers

PK Mito Dyes: minimally phototoxic fluorophores for mitochondrial imaging/analysis in live & fixed cells
with Christian Jüngst (Cologne), Stefan Jakobs lab (Max Planck), Liangyi Chen lab (PKU), & Kai Lei lab (Westlake U)
Chem Sci 2020, PNAS 2022, PNAS 2024

PNAS cover story
Chemical Science Most popular 2019-2020 chemical biology articles
News and Highlights: ScienceNet.cn （中国科学报）

Gentle Rhodamines: COT conjugation can generally reduce the phototoxicity of rhodamines for live cell imaging
With Kai Johnsson lab (Max Planck) and Lu Wang Lab (Fudan)
ACS Central Science 2024
PK Zinc Dyes: minimally phototoxic zinc indicators for multiplexed recording of insulin secretion
with Liangyi Chen lab (PKU) & Chao Tang lab (PKU)
ACIE 2021, Nat. Metabolism 2024, ChemEU 2022 (invited review), Chem&Biomed Imaging 2025

Angewandte Chemie Inside Cover

Cy-POD: The Cys-conjugated Cy dyes are more prone to photobleaching than those labeled through amide bonds. Here is our Why and How.
with Chunlai Chen lab (THU)
JACS 2023
CurrOpinChemBio 2024 (invited review)
Gentle Voltage Sensors: long term imaging of membrane potentials in primary cells
with Peng Zou lab (PKU)
PNAS 2023
Covalent TMP-tag (Now 3rd generation): live cell protein labeling technology for advanced optical imaging
A heritage of Prof. Virginia Cornish @Columbia
ACIE 2022
JACS 2012, CurrOpinChemBio 2013, ChemComm 2016

Vibrational palette: visualization of multiplexed molecular targets under stimulated Raman scattering microscopy
@Columbia with Prof. Wei Min and colleagues
JACS 2014, ACIE 2015, Nature 2017

Ladderene unzipping: transformation of an insulating polymer into a semiconductor by ultrasonic pulling force
@Stanford with Prof. Yan Xia and colleagues
Science 2017, NatChem 2020
Schindilactone A total synthesis: making a complex Chinese natural product from scratch
@PKU with Profs. Zhen Yang, Jiahua Chen and colleagues
ACIE 2011, ChemAsianJ 2012
Publications
Selected papers highlighted. # equal contribution. * corresponding authors
(Preprint) Zhang, J.; et al. A Palette of Bridged Bicycle-Strengthened Fluorophores. bioRxiv Dec. 23 2024
(Preprint) Yang, Z.; et al. Zou, P.*; Chen, Z.* Spatially barcoding biochemical reactions using DNA nanostructures unveil a major contact mechanism in proximity labeling. bioRxiv Dec. 18 2024
(Preprint) Ling, J.#; Liu, Y.#; et al A gentle palette of plasma membrane dyes. bioRxiv May. 04 2024

(47) Yu, R.#; Zhang, J.#; Peng, X.*; Chen, Z.*; Bright Zinc Probes with Thiomorpholine Monoxide Auxochromes for Imaging Insulin Secretion. Chemical & Biomedical Imaging 2025, in press
(46) Papereux, S.; Leconte, L.; Valades-Cruz, C. A.; Liu, T.; Dumont, J.; Chen, Z.; Salamero, J.; Kervrann, C.; Badoual, A.* DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images. Communications Biology 2025, 8, 320
(45) Cao, R. et al.; Chen, Z.; Li, M.*; Xi, P.* Fast reconstruction and optical-sectioning three-dimensional structure illumination microscopy. The Innovation. 2025, 6, 100757
(44) Pan, X. et al.; Chen, L.*; Chen, Z.*; Lei, K.* Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance. Nat. Commun. 2024, 15, 10681.
(43) Zhang, K.#; Duan, J.#; Li, C.*; Song, C.; Chen, Z.* How Do DNA Molecular Springs Modulate Protein–Protein Interactions: Experimental and Theoretical Results. Biochemistry 2024, 63, 3369-80
(42) Liu, T.#; Kompa, J.#; Ling, J.#; Lardon, N.; Zhang, Y.; Chen, J.; Reymond, L.; Chen, P.; Tran, M.; Yang, Z.; Zhang, H.; Liu, Y.; Pitsch, S.; Zou, P.; Wang, L.; Johnsson, K.; Chen, Z.* Gentle rhodamines for live-cell fluorescence microscopy. ACS Cent. Sci. 2024, 10, 1933-44.
(41) Chen, J.; Stephan, T.; Gaedke, F.; Liu, T.; Li, Y. Schauss, A.; Chen, P.; Wulff, V.; Jakobs, S.; Jüngst, C.*; Chen, Z.* An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells. PNAS 2024, 121, e2317703121.
(40) Zhang, Y.; Yang, Z.; Dilizhatai, S.; Shen, X.; Ye, J.; Yu, B.; Pefaur, N.; Scheer, J. M.; Nixon, A. E.*; Chen, Z.* Geometric Antibody Engineering Reveals the Spatial Factor on the Efficacy of Bispecific T Cell Engagers. ACS Chem. Biol. 2024, 19, 916-25
(39) Zhang, Y.;Ling, J.; Liu, T.; Chen, Z.* Lumos maxima – How robust fluorophores resist photobleaching? Curr. Opin. Chem. Biol. 2024, 79, 102439 [invited review]
(38) Peng, X.#; Ren, H.#; Yang, L.#; Tong, S.#; et al.; Chen, Z.; Liu, H.*; Chen, L*. Readily releasable β cells with tight Ca²⁺–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion. Nat. Metablism 2024, 6, 238-53
(37) Li, C.#; Cheng, K.#; Zhao, Q.#; et al.; Quan, L.*; Chen, Z.* Diazo-carboxyl Click Derivatization Enables Sensitive Analysis of Carboxylic Acid Metabolites in Biosamples. Anal. Chem. 2023, 95, 16976.
(36) Dilizhatai, S.; Chen, Z.* Chemical tags and beyond: Live-cell protein labeling technologies for modern optical imaging. Smart Molecules. 2023, 1, e20230002.
(35) Liu, S.#; Ling, J.#; et al.; Zou, P.*; Chen, Z.* Orange/far-red hybrid voltage indicators with reduced phototoxicity enable reliable long-term imaging in neurons and cardiomyocytes. PNAS 2023, 120, e2306950120.
(34) Yang, X.; Chen, D.; Sun, Q. et al.; Chen, Z.; Liu, Y.*; Zhang, J.*; Zhao, Y.* A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems. Cell Discov. 2023, 9, 53.
(33) Yu, Q.; Yao, Z.; Zhang, H.; Li, Z.; Chen, Z.; Xiong, H.* Transient Stimulated Raman Excited Fluorescence Spectroscopy. J. Am. Chem. Soc. 2023, 145, 7758-62.
(32) Zhang, Y.#; Yang, C.#; Peng, S.; Ling, J.; Chen, P.; Ma, Y.; Wang, W.; Chen, Z.*; Chen, C.* General Strategy To Improve the Photon Budget of Thiol-Conjugated Cyanine Dyes. J. Am. Chem. Soc. 2023, 145, 4187-98.
(31) Liu, T.^#; Stephan, T.^#; Chen, P.; Keller-Findeisen, J.; Chen, J.; Riedel, D.; Yang, Z.; Jakobs, S.; Chen, Z.* Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. PNAS 2022, 119, e2215799119 [Cover]
(30) Mo, J.^#; Chen, J.^#; Shi, Y.; Sun, J.; Wu, Y.; Liu, T.; Zhang, J.; Zheng, Y.; Li, Y.; Chen, Z.* Third-Generation Covalent TMP-Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins. Angew. Chem. Int. Ed. 2022, 61, e202207905
(29) Liu, M.^#; Zhang, J.^#; Chen, Z.* Emerging trends in fluorescence bioimaging of divalent metal cations using small-molecule indicators. Chem. Eur. J. 2022, 28, e202200587. [Invited Review]
(28) Du, J.; Zheng, L.; Gao, P.; Yang, H.; Yang, W.-J.; Guo, F.; Liang, R.; Feng, M.; Wang, Z.; Zhang, Z.; Bai, L.; Bu, Y.; Xing, S.; Zheng, W.; Wang, X.; Quan, L.; Hu, X.; Wu, H.; Chen, Z.; Chen, L.; Wei, K.; Zhang, Z.; Zhu, X.; Zhang, X.; Tu, Q.; Zhao, S.-M.*; Lei, X.*; Xiong, J.-W.* A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell 2022, 29, 545-58.
(27) Niu, Y.; Liu, R.; Guan, C.; Zhang, Y.; Chen, Z.; Hoerer, S.; Nar, H.; Chen, L.* Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter. Nature 2022, 601, 280-4.
(26) Zhang, J.^#; Peng, X.^#; Wu, Y.^#; Ren, H.^#; Sun, J.; Tong, S.; Liu, T.; Zhao, Y.; Wang, S.; Tang, C.; Chen, L.; Chen, Z.* Red- and Far-Red-Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion. Angew. Chem. Int. Ed. 2021, 60, 25846-55. [Inside Cover]
(25) Yang, Z.^#; Li, L.^#; Ling, J.; Liu, T.; Huang, X.; Ying, Y.; Zhao, Y.; Zhao, Y.; Lei, K.*; Chen, L.*; Chen, Z.* Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging. Chem. Sci. 2020, 11, 8506-8516.

(24) Chen, Z.^#; Zhu, X.^#; Yang, J.; Mercer, J. A. M.; Burns, N. Z.; Martinez, T. J.; Xia, Y. The cascade unzipping of ladderane reveals dynamic effects in mechanochemistry. Nat. Chem. 2020, 12, 302-309.
(23) Su, J. K.; Feist, J. D.; Yang, J.; Mercer, J. A. M.; Romaniuk, J. A. H.; Chen, Z.; Cegelski, L.; Burns, N. Z.; Xia, Y. Synthesis and Mechanochemical Activation of Ladderene–Norbornene Block Copolymers. J. Am. Chem. Soc. 2018, 140, 12388.
(22) Shi, L.; Zheng, C.; Shen, Y.; Chen, Z.; Silveira, E. S.; Zhang, L.; Wei, M.; Liu, C.; de Sena-Tomas, C.; Targoff, K.; Min, W. Optical imaging of metabolic dynamics in animals. Nature Communications 2018, 9, 2995.
(21) Qiao, Y.; Zhou, Z.; Chen, Z.; Du, S.; Cheng, Q.; Zhai, H.; Fritz, N. J.; Du, Q.; Yang, Y. Visualizing ion diffusion in battery systems by fluorescence microscopy: A case study on the dissolution of LiMn₂O_4. Nano Energy 2018, 45, 68.
(20) Chen, Z.; Mercer, J. A. M.; Zhu, X.; Romaniuk, J. A. H.; Pfattner, R.; Cegelski, L.; Martinez, T. J.; Burns, N. Z.; Xia, Y. Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene. Science 2017, 357, 475-479 [Front Cover].
(19) Wei, L.; Chen, Z.; Shi, L.; Long, R.; Anzalone, A. V.; Zhang, L.; Hu, F.; Yuste, R.; Cornish, V. W.; Min, W. Super-multiplex vibrational imaging. Nature 2017, 544, 465-470.
(18) Wei, L.; Hu, F.; Chen, Z.; Shen, Y.; Zhang, L.; Min, W., Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes. Acc. Chem. Res. 2016, 49, 1494-1502
(17) Anzalone, A. V; Chen, Z.; Cornish, V. W. Synthesis of Photoactivatable Azido-acyl Caged Oxazine Fluorophores for Live-cell Imaging. Chem. Commun. (Camb). 2016, 52, 9442-9445
(16) Freyer, J. L.; Brucks, S. D.; Gobieski, G. S.; Russell, S. T.; Yozwiak, C. E.; Sun, M.; Chen, Z.; Jiang, Y.; Bandar, J. S.; Stockwell, B. R.; Lambert, T. H.; Campos, L. M., Clickable Poly(ionic liquids): A Materials Platform for Transfection. Angew. Chem. Int. Ed. 2016, 55, 12382-12386
(15) Hu, F.; Chen, Z.; Zhang, L.; Shen, Y.; Wei, L.; Min, W. Vibrational Imaging of Glucose Uptake Activity in Live Cells and Tissues by Stimulated Raman Scattering. Angew. Chem. Intl. Ed. 2015, 54, 9821-9825
(14) Chen, Z.; Paley, D. W.; Wei, L.; Weisman, A. L.; Friesner, R. A.; Nuckolls, C.; Min, W. Multicolor Live-Cell Chemical Imaging by Isotopically Edited Alkyne Vibrational Palette. J. Am. Chem. Soc. 2014, 136, 8027–8033.
(13) Wei, L.; Hu, F.; Shen, Y.; Chen, Z.; Yu, Y.; Lin, C.-C.; Wang, M. C.; Min, W. Live-Cell Imaging of Alkyne-Tagged Small Biomolecules by Stimulated Raman Scattering. Nat. Methods 2014, 11, 410–412.
(12) Chen, Z.; Cornish, V. W.; Min, W. Chemical Tags: Inspiration for Advanced Imaging Techniques. Curr. Opin. Chem. Biol. 2013, 17, 637–643.
(11) Anzalone, A. V; Wang, T. Y.; Chen, Z.; Cornish, V. W. A Common Diaryl Ether Intermediate for the Gram-Scale Synthesis of Oxazine and Xanthene Fluorophores. Angew. Chem. Int. Ed. Engl. 2013, 52, 650–654.
(10) Xu, F.; Wei, L.; Chen, Z.; Min, W. Frustrated FRET for High-Contrast High-Resolution Two-Photon Imaging. Opt. Express 2013, 21, 14097–14108.
(9) Zhang, L.; Xu, F.; Chen, Z.; Zhu, X.; Min, W. Bioluminescence Assisted Switching and Fluorescence Imaging (BASFI). J. Phys. Chem. Lett. 2013, 4, 3897–3902.
(8) Chen, Z.; Jing, C.; Gallagher, S. S.; Sheetz, M. P.; Cornish, V. W. Second-Generation Covalent TMP-Tag for Live Cell Imaging. J. Am. Chem. Soc. 2012, 134, 13692–13699.
(7) Gatzogiannis, E.^#; Chen, Z.^#; Wei, L.; Wombacher, R.; Kao, Y.-T.; Yefremov, G.; Cornish, V. W.; Min, W. Mapping Protein-Specific Micro-Environments in Live Cells by Fluorescence Lifetime Imaging of a Hybrid Genetic-Chemical Molecular Rotor Tag. Chem. Commun. (Camb). 2012, 48, 8694–8696.
(6) Chen, Z.^#; Wei, L.^#; Zhu, X.^#; Min, W. Extending the Fundamental Imaging-Depth Limit of Multi-Photon Microscopy by Imaging with Photo-Activatable Fluorophores. Opt. Express 2012, 20, 18525–18536.
(5) Wei, L.; Chen, Z.; Min, W. Stimulated Emission Reduced Fluorescence Microscopy: A Concept for Extending the Fundamental Depth Limit of Two-Photon Fluorescence Imaging. Biomed. Opt. Express 2012, 3, 1465–1475.
(4) Li, Y.; Chen, Z.-X.; Xiao, Q.; Ye, Q.-D.; Sun, T.-W.; Meng, F.-K.; Ren, W.-W.; You, L.; Xu, L.-M.; Wang, Y.-F.; et al. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 2: Construction of the Fully Functionalized CDEFGH Ring System. Chem. Asian J. 2012, 7, 2334–2340.
(3) Ren, W.-W.; Chen, Z.-X.; Xiao, Q.; Li, Y.; Sun, T.-W.; Zhang, Z.-Y.; Ye, Q.-D.; Meng, F.-K.; You, L.; Zhao, M.-Z.; et al. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 3: The Final Phase and Completion. Chem. Asian J. 2012, 7, 2341–2350.
(2) Xiao, Q.^#; Ren, W.-W.^#; Chen, Z.-X.; Sun, T.-W.; Li, Y.; Ye, Q.-D.; Gong, J.-X.; Meng, F.-K.; You, L.; Liu, Y.-F.; et al. Diastereoselective Total Synthesis of (±)-Schindilactone A. Angew. Chem. Int. Ed. Engl. 2011, 50, 7373–7377 [Front Cover].
(1) Wang, L.; Gong, J.; Deng, L.; Xiang, Z.; Chen, Z.; Wang, Y.; Chen, J.; Yang, Z. Formal Total Synthesis of N-Methylmaysenine. Org. Lett. 2009, 11, 1809–1812.
Samples
It's our pleasure to distribute our products to promote your research, contact Dr. Chen for material requests

PK Mito Red/DeepRed/Orange

PK Mito dyes feature reduced phototoxicity and stem-cell biocompatibility, enabling STED and Hessian-SIM imaging under super-resolution.

Refer to publications #25 and #31 for details.

Commercial Sources:

China:
http://www.genvivotech.com/products

International:
https://spirochrome.com/

Laboratory of Molecular Probe Technology

College of Future Technology,Institute of Molecular Medicine,National Biomedical Imaging Center,Peking-Tsinghua Center for Life Sciences,Peking University

Research Philosophy

Tailored Molecules for Advanced Imaging and Biotechnology

Meet Our Team

Dr. Zhixing Chen 陈知行 博士

Principal Investigator

Cong Li 李聪

PostDoc

TianYan Liu 刘天妍

PostDoc (Boya Fellow)

JunWei Zhang 张钧维

PhD

JingTing Chen 陈婧婷

Graduate Student

ZhongTian Yang 杨中天

Graduate Student

RunDong Yu 于润东

Graduate Student

KeCheng Zhang 张珂诚

Graduate Student

Zhe Yang 杨哲

Graduate Student

MingQiao Liu 刘明樵

Graduate Student

YiTong Liu 刘奕彤

Graduate Student

Dilizhatai Saimi迪丽扎泰·赛米

Graduate Student

XiaoWen Shen 沈潇雯

Graduate Student

ZhengZhao Chen 陈正昭

Graduate Student

JiaSheng Du 杜佳晟

Graduate Student

HaoLin Zhang 张昊霖

Research Assistant

Past Members and their Next Destination

Selected Projects

Our research achievements using elaborately tailored molecules to advance science at different frontiers

PK Mito Dyes: minimally phototoxic fluorophores for mitochondrial imaging/analysis in live & fixed cells

with Christian Jüngst (Cologne), Stefan Jakobs lab (Max Planck), Liangyi Chen lab (PKU), & Kai Lei lab (Westlake U)

Gentle Rhodamines: COT conjugation can generally reduce the phototoxicity of rhodamines for live cell imaging

With Kai Johnsson lab (Max Planck) and Lu Wang Lab (Fudan)

PK Zinc Dyes: minimally phototoxic zinc indicators for multiplexed recording of insulin secretion

with Liangyi Chen lab (PKU) & Chao Tang lab (PKU)

Cy-POD: The Cys-conjugated Cy dyes are more prone to photobleaching than those labeled through amide bonds. Here is our Why and How.

with Chunlai Chen lab (THU)

Gentle Voltage Sensors: long term imaging of membrane potentials in primary cells

with Peng Zou lab (PKU)

Covalent TMP-tag (Now 3rd generation): live cell protein labeling technology for advanced optical imaging

A heritage of Prof. Virginia Cornish @Columbia

Vibrational palette: visualization of multiplexed molecular targets under stimulated Raman scattering microscopy

@Columbia with Prof. Wei Min and colleagues

Ladderene unzipping: transformation of an insulating polymer into a semiconductor by ultrasonic pulling force

@Stanford with Prof. Yan Xia and colleagues

Schindilactone A total synthesis: making a complex Chinese natural product from scratch

@PKU with Profs. Zhen Yang, Jiahua Chen and colleagues

Publications

Selected papers highlighted. # equal contribution. * corresponding authors

Samples

It's our pleasure to distribute our products to promote your research, contact Dr. Chen for material requests

PK Mito Red/DeepRed/Orange

College of Future Technology,
Institute of Molecular Medicine,
National Biomedical Imaging Center,
Peking-Tsinghua Center for Life Sciences,
Peking University

Dr. Zhixing Chen 陈知行博士

Dilizhatai Saimi
迪丽扎泰·赛米